If you’re looking for a quick, comforting meal with a Mexican twist, this Mexican Lasagna recipe is the perfect choice! Layered with rows of tortillas, chicken, cheese and salsa, this dish is full of flavor and the perfect recipe for an easy weeknight dinner. Plus, kids love it!

Mexican Lasagna in baking dish.Pin
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Why I Love This Recipe

  • So Simple: Just like my Mexican Enchiladas recipe, this dish comes together super fast, especially if you use a rotisserie chicken from the grocery store. It’s ideal for those nights when you need a delicious dinner ASAP.
  • Kid-Friendly: When it comes to lasagna, whether it’s this dish, Vegetarian Skillet Lasagna or Lasagna Rolls, part of the fun is layering the dish. It’s a great way to get kids involved in the kitchen and encourage them to try new foods! Let the little ones place the tortillas while you handle the chicken and cheese.
  • Great for a Crowd: This Mexican Lasagna recipe is great if you’re looking to feed a crowd. It also freezes beautifully, so you can enjoy it any time. Or put leftovers in your kid’s school lunch with some avocado slices and call it a day!
  • Customizable: You can easily swap in ingredients or add extras like black beans, sautéed veggies, or different cheeses.

The Ingredients

Mexican lasagna ingredients.Pin
  • Corn tortillas: Tortillas replace lasagna noodles in this casserole with a Mexican inspired twist.
  • Egg: Helps bind the ingredients together for a rich, hearty filling.
  • Milk: Adds a bit of moisture and creaminess to the filling.
  • Sour cream: Brings a tangy, creamy element that makes the lasagna extra delicious.
  • Chunky salsa: Choose your favorite mild salsa for a boost of flavor—chunky is best for texture!
  • Chicken breast, cooked and shredded: Using a rotisserie chicken is a great time-saver, or you can make your own Slow Cooker Mexican Chicken and shred it.
  • Cream cheese: These little cubes melt into the lasagna, adding pockets of creamy goodness.
  • Fresh cilantro: Brightens up the flavors and adds a pop of freshness.
  • Scallions: Provide a mild onion flavor that complements the other ingredients.
  • Mexican cheese blend (or Monterey Jack & Mild Cheddar): Melty cheese is a must in lasagna, and this blend gives just the right cheesy goodness!

Variations and Substitutions

This Mexican Lasagna recipe is super flexible, so feel free to mix it up with these variations!

  • Switch the Protein: Swap out the chicken for ground beef, turkey, or even a vegetarian option like cubed firm tofu, sautéed vegetables, black beans or your favorite sautéed plant based meat substitute.
  • Add Veggies: Try layering in sautéed bell peppers, zucchini, or corn for extra color and nutrition.
  • Use Flour Tortillas: If you prefer, you can use flour tortillas instead of corn. The texture will be softer, but just as delicious!
  • Spice it Up: Want more heat? Use a medium or hot salsa, or add diced jalapeños into the chicken mixture.

How to Make Mexican Lasagna

Tortillas spritzed with cooking oil on a baking sheet.Pin

Step 1: Preheat oven to 350°F. Place the tortillas on an oil sprayed baking sheet, then spray the tops with additional oil. Bake for 8-10 minutes, remove and set aside.

Chicken mixture for Mexican lasagna in a mixing bowl.Pin

Step 2: In a large bowl, whisk one egg. Add the milk, sour cream, salsa, shredded chicken, cubed cream cheese, cilantro, scallions and salt. Stir to combine.

Tortillas, chicken mixture and shredded cheese layered in baking dish.Pin

Step 3: Arrange half of the par-baked tortillas on the bottom of an oil sprayed 7×11 baking dish. Layer half the chicken mixture on top of the tortillas, then layer 1 cup of the cheese blend on top.

Layered mexican lasagna in baking dish.Pin

Step 4: Continue to layer the rest of the tortillas on top, followed by the remaining chicken mixture and cheese.

Mexican Lasagna topped with sliced avocado.Pin

Step 5: Bake uncovered for 35 minutes. Serve.

Tips and Tricks

  • Par-bake the tortillas: This step is key to keeping the layers from becoming soggy.
  • Make it ahead: Assemble the lasagna up to a day ahead, then cover and refrigerate until ready to bake.
  • Freezing: You can freeze the lasagna either before or after baking. If freezing before, simply bake from frozen, adding an extra 10-15 minutes of cook time.

FAQs

Can I use flour tortillas instead of corn tortillas for Mexican Lasagna?

Absolutely! Flour tortillas work just as well and can be swapped 1:1.

What’s the best salsa for this recipe?

Especially if you are serving this to kids, a mild, chunky salsa works best to balance the flavors, but if you like a little more heat, feel free to use medium or hot salsa.

A serving of Mexican lasagna on a plate next to the casserole dish.Pin

More Mexican Inspired Entrées

This Mexican Lasagna recipe is a family favorite in my kitchen! It’s quick to make, full of flavor, and super customizable. Whether you’re serving it for a weeknight dinner or meal-prepping for the week, this dish is sure to be a hit! Let me know what you think by leaving a comment and rating below!

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Mexican Lasagna

Layered with rows of tortillas, chicken, cheese and salsa, Mexican Lasagna is the perfect recipe for an easy weeknight dinner that's full of flavor!
5 from 2 votes
Course: Main Dish
Cuisine: Mexican
Servings: 6
Prep Time 10 minutes
Cook Time 35 minutes
Total Time 45 minutes

Ingredients  

  • cooking oil spray
  • 6 corn tortillas
  • 1 large egg
  • 1/4 cup milk
  • 1/4 cup sour cream
  • 1 cup mild chunky salsa
  • 1 pound chicken breast, cooked and shredded
  • 4 ounces cream cheese, cubed
  • 2 tablespoons fresh cilantro, chopped
  • 3 scallions, chopped
  • 1 teaspoon kosher salt
  • 2 cups Mexican cheese blend (or a blend of Monterey Jack and Mild Cheddar), divided

Instructions 

  • Preheat oven to 350°F.
  • Place the tortillas on an oil sprayed baking sheet, then spray the tops with additional oil.
  • Bake for 8-10 minutes, remove and set aside.
  • In a large bowl, whisk one egg. Add the milk, sour cream, salsa, shredded chicken, cubed cream cheese, cilantro, scallions and salt. Stir to combine.
  • Arrange half of the par-baked tortillas on the bottom of an oil sprayed 7×11 baking dish. Layer half the chicken mixture on top of the tortillas, then layer 1 cup of the cheese blend on top.
  • Continue to layer the rest of the tortillas on top, followed by the remaining chicken mixture and cheese.
  • Bake uncovered for 35 minutes.

Notes

  • Par-bake the tortillas: This step is key to keeping the layers from becoming soggy.
  • Make it ahead: Assemble the lasagna up to a day ahead, then cover and refrigerate until ready to bake.
  • Freezing: You can freeze the lasagna either before or after baking. If freezing before, bake from frozen, adding an extra 10-15 minutes of cook time.

Nutrition

Calories: 330kcal | Carbohydrates: 13g | Protein: 22g | Fat: 22g | Cholesterol: 85mg | Sodium: 760mg | Fiber: 2g | Sugar: 2g
Did you make this recipe?Mention @Weelicious or tag #weelicious!

About the Author

Catherine is a mama of three. A Kentucky girl living in California. Here’s what I know: all kids can be great eaters and mealtime must be easy. I create simple, healthy recipes the whole family will love.

Comments

  1. This is so crazy delicious and easy! Cooking the chicken in the crockpot ahead of time made the chicken so moist and easy to shred. No need to add any spices or liquid to the chicken!

  2. I made this last night and it was delicious and a big hit with everyone including my three year old. Also added some extra cheese & topped it with black olives sprinkled on the top before baking. Weelicious is always my go to site or I’ll look in the cookbook which I love.

  3. I made this last night, increased the size of the pan to a 9×13 and added in loads of beans, corn and other veggies (and a little extra salsa. It was delicious! And, my 14 month old actually ate the chicken – a first! Thanks for the recipe!

5 from 2 votes (1 rating without comment)

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